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Neuropsychopharmacology. 2001 Nov;25(5):793-5.

Hypothalamic-pituitary-adrenal axis dysregulation in depersonalization disorder.

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1
Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA. daphne.simeon@mssm.edu

Abstract

BACKGROUND:

The purpose of this preliminary study was to investigate HPA axis function in dissociation.

METHODS:

Nine subjects with DSM-IV depersonalization disorder (DPD), without lifetime Posttraumatic Stress Disorder (PTSD) or current major depression, were compared to nine healthy comparison (HC) subjects of comparable age and gender.

RESULTS:

DPD subjects demonstrated significant hyposuppression to low-dose dexamethasone administration and significantly elevated morning plasma cortisol levels when covaried for depression scores, but no difference in 24-hour urinary cortisol excretion. Dissociation scores powerfully predicted suppression whereas depression scores did not contribute to the prediction.

CONCLUSIONS:

Primary dissociative conditions, such as depersonalization disorder, may be associated with a pattern of HPA axis dysregulation that differs from PTSD and merits further study.

PMID:
11682263
DOI:
10.1016/S0893-133X(01)00288-3
[Indexed for MEDLINE]
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