Format

Send to

Choose Destination
See comment in PubMed Commons below
Behav Brain Res. 2001 Nov 1;125(1-2):127-32.

Genetic dissection of mouse exploratory behaviour.

Author information

1
Brudnick Neuropsychiatric Research Institute, Room 111B, University of Massachusetts Medical School, 303 Belmont Street, Worcester, MA 01604, USA. wim.crusio@umassmed.edu

Abstract

A large variety of apparatus and procedures are being employed to measure mouse exploratory behaviour. Definitions of what constitutes exploration also vary widely. The present article reviews two studies whose results permit a genetic dissection of behaviour displayed in an open-field situation. The results agree that factors representing exploration and stress/fear underlie this type of behaviour. Both factors appear to be linked to neuroanatomical variation in the sizes of the hippocampal intra- and infrapyramidal mossy fibre terminal fields. Multivariate analysis of genetic correlations may render important insights into the structure of behaviour and its relations with neuroanatomical and neurophysiological systems.

PMID:
11682103
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center