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J Hepatol. 2001 Oct;35(4):512-6.

Interferon plus amantadine versus interferon alone in the treatment of naïve patients with chronic hepatitis C: a UK multicentre study.

Author information

1
Department of Medicine, St Mary's Hospital ICSM, London, UK.

Abstract

BACKGROUND/AIMS:

The antiviral agent amantadine may have activity against the hepatitis C virus. To determine whether the combination of interferon-alpha plus amantadine was more effective than interferon monotherapy we conducted a multicentre clinical trial in untreated patients with chronic hepatitis C infection.

METHODS:

We performed a pilot study in two centres (36 patients) to determine the number needed for a statistically significant clinical trial and then conducted a multicentre, randomized controlled clinical trial involving 14 centres and 143 patients.

RESULTS:

There was no significant difference in sustained response rates in patients receiving interferon and amantadine compared to those receiving interferon alone. The on treatment response rate at 3 months was 65% on combination vs. 49% on interferon alone (P = 0.05) while the sustained response was 18 and 15%, respectively.

CONCLUSIONS:

Combination therapy with interferon plus amantadine does not lead to a significant increase in sustained response rates when compared to interferon monotherapy.

PMID:
11682036
DOI:
10.1016/s0168-8278(01)00140-4
[Indexed for MEDLINE]

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