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J Antimicrob Chemother. 2001 Nov;48(5):627-30.

An integron-associated beta-lactamase (IBC-2) from Pseudomonas aeruginosa is a variant of the extended-spectrum beta-lactamase IBC-1.

Author information

1
Laboratory of Bacteriology, Hellenic Pasteur Institute, Athens, Greece.

Abstract

An extended-spectrum beta-lactamase, IBC-2, produced by a clinical strain of Pseudomonas aeruginosa, was characterized. bla(IBC-2) was found, as a gene cassette, to be the sole gene within the variable region of a class 1 integron probably located in the chromosome. IBC-2 is a variant of IBC-1 and GES-1, differing by one amino acid from each of these beta-lactamases. When expressed in Escherichia coli, IBC-2 was observed to confer resistance to ceftazidime and decreased susceptibility to other oxyimino-beta-lactams.

PMID:
11679551
DOI:
10.1093/jac/48.5.627
[Indexed for MEDLINE]

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