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Bioorg Med Chem Lett. 2001 Nov 19;11(22):2959-62.

Identification of a series of PPAR gamma/delta dual agonists via solid-phase parallel synthesis.

Author information

1
Nuclear Receptor Discovery Research, GlaxoSmithKline, Research Triangle Park, NC 27709, USA. kevin_liu@stromix.com

Abstract

We have developed a general solid-phase synthesis for identification of PPAR ligands. Synthesis of a 480-member library led to the identification of a potent PPAR gamma/delta dual agonist 23. Compound 23 showed good plasma exposure in rats and demonstrated antihyperglycemic and antihyperlipidemic efficacy in diabetic fatty Zucker rats.

PMID:
11677135
DOI:
10.1016/s0960-894x(01)00596-0
[Indexed for MEDLINE]

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