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Bioorg Med Chem Lett. 2001 Nov 19;11(22):2951-4.

Discovery and parallel synthesis of a new class of cathepsin K inhibitors.

Author information

1
Department of Chemistry Research, Bayer Research Center, 400 Morgan Lane, West Haven, CT 06516, USA. roger.smith.b@bayer.com

Abstract

Peptidomimetic aminomethyl ketones have been identified as a new class of cathepsin K inhibitors. Traditional and high-speed parallel synthesis techniques were applied to investigate this series. Structure-activity relationships were established, and certain analogues were characterized with IC(50) values in the range 200-500 nM.

PMID:
11677133
DOI:
10.1016/s0960-894x(01)00600-x
[Indexed for MEDLINE]

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