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Nihon Rinsho. 2001 Oct;59(10):1894-9.

[Inflammatory cytokines (IL-4, IL-5 and IL-13)].

[Article in Japanese]

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Clinical Research Center, National Sagamihara Hospital.


The polarized Th2 cells play an important role in the pathogenesis of atopic asthma as well as in the induction of airway inflammation. Th2 cytokines, such as IL-4, IL-5 and IL-13, are pivotal in regulating the allergic phenotype, the IgE response or the inflammatory cell-mediated function. Selective inhibition of Th2 cytokines by pharmacologic agents, including anti-cytokine blocking antibody, cytokine mutant and soluble cytokine receptor, will contribute to asthma therapy. Strategies based on blocking key signaling cytokines are also discussed.

[Indexed for MEDLINE]

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