Axinellamines A-D, Novel Imidazo-Azolo-Imidazole Alkaloids from the Australian Marine Sponge Axinella sp

Sylvia Urban; Priscila de Almeida Leone; Anthony R. Carroll; Gregory A. Fechner; Jill Smith; John N. A. Hooper; Ronald J. Quinn

doi:10.1021/jo981034g

Axinellamines A-D, Novel Imidazo-Azolo-Imidazole Alkaloids from the Australian Marine Sponge Axinella sp

J Org Chem. 1999 Feb 5;64(3):731-735. doi: 10.1021/jo981034g.

Authors

Sylvia Urban¹, Priscila de Almeida Leone, Anthony R. Carroll, Gregory A. Fechner, Jill Smith, John N. A. Hooper, Ronald J. Quinn

Affiliation

¹ Queensland Pharmaceutical Research Institute, Griffith University, Brisbane, Queensland 4111, Australia, and Queensland Museum, South Brisbane, Queensland 4101, Australia.

PMID: 11674140
DOI: 10.1021/jo981034g

Abstract

Four imidazo-azolo-imidazole alkaloids, axinellamines A-D, have been isolated from an Australian marine sponge, Axinella sp. (order: Halichondrida: family: Axinellidae). These compounds contain a unique perhydrocyclopenta-imidazo-azolo-imidazole carbon skeleton. Three of these compounds had bactericidal activity against Helicobacter pylori at 1000 &mgr;M.