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Int J Obes Relat Metab Disord. 2001 Oct;25(10):1416-20.

C-reactive protein is independently associated with total body fat, central fat, and insulin resistance in adult women.

Author information

1
Department of Emergency and Transplant, Section of Internal Medicine, Endocrinology and Metabolic Diseases, University of Bari, Bari, Italy.

Abstract

OBJECTIVE:

To investigate whether C-reactive protein (CRP) concentrations are influenced by body composition, insulin resistance, and body fat distribution in healthy women.

DESIGN:

Cross-sectional study of CRP plasma levels in adult women.

SUBJECTS:

A total of 201 apparently healthy normal weight, overweight, and obese women, aged 18-60 y.

MEASUREMENTS:

CRP plasma levels, several fatness and body fat distribution parameters (by bioimpedance analysis and anthropometry), and insulin resistance (HOMA(IR)), as calculated by homeostatic model assessment.

RESULTS:

CRP was positively correlated with age, body mass index (BMI), waist, fasting glucose and insulin, HOMA(IR), fat-free mass (FFM) and fat mass (FM). After multivariate analyses, age, HOMA(IR), waist and FM maintained their independent association with CRP.

CONCLUSION:

Our study has shown an independent relationship of central fat accumulation and insulin resistance with CRP plasma levels, thus suggesting that mild, chronic inflammation may be a further component of the metabolic syndrome and a mediator of the atherogenic profile of this syndrome.

PMID:
11673760
DOI:
10.1038/sj.ijo.0801719
[Indexed for MEDLINE]

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