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Antiviral Res. 2001 Nov;52(2):91-8.

Immunopathogenesis of hepatitis B e antigen negative chronic hepatitis B infection.

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Academic Department of Medicine, Hippokration General Hospital, 114 Vas. Sophias Avenue, 115 27 Athens, Greece.


Hepatitis B e antigen (HBeAg) negative chronic hepatitis B represents currently the predominant form of chronic hepatitis due to the hepatitis B virus (HBV) in several parts of the world. In this review, recent data regarding the process of HBeAg negative HBV strain selection during the course of chronic HBV infection are presented and the potential virus and/or host-mediated mechanisms that lead to chronic liver necroinflammation, i.e. chronic hepatitis are outlined.

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