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Eur J Pharmacol. 2001 Jul 27;424(3):R3-4.

Group I metabotropic glutamate receptors limit AMPA receptor-mediated oligodendrocyte progenitor cell death.

Author information

1
School of Biomedical and Life Sciences, University of Surrey, Guildford, Surrey GU2 7XH, UK.

Abstract

Oligodendrocyte progenitor cells were found to be vulnerable to kainate excitotoxic insults, an effect inhibited by either the selective alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist (1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine (GYKI 52466)) or the selective group I metabotropic glutamate (mGlu) receptor agonist, (S)-3,5-dihydroxyphenylglycine. The protective effects of (S)-3,5-dihydroxyphenylglycine were reversed by the selective mGlu receptor antagonist, (S)-alpha-methyl-4-carboxyphenylglycine. These data suggest that group I mGlu receptors may limit oligodendrocyte progenitor cell degeneration during acute brain insults.

PMID:
11672568
DOI:
10.1016/s0014-2999(01)01157-8
[Indexed for MEDLINE]

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