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Immunity. 2001 Oct;15(4):497-502.

Signaling takes a breath--new quantitative perspectives on bioenergetics and signal transduction.

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Department of Medicine, Division of Endocrinology and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, MA 02215, USA.


Immune cells are in constant need of energy for both basic housekeeping and specific immune functions. Increased energy demand during lymphocyte stimulation is coordinated by signal transduction pathways. This review explores the interface between lymphocyte signaling and energy metabolism. In particular, it discusses recent work that allows weighing signaling routes with respect to their role in the regulation of energy metabolism during lymphocyte activation.

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