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Respir Res. 2000;1(1):40-8. Epub 2000 Jul 3.

Hypoxic pulmonary vasoconstriction: role of voltage-gated potassium channels.

Author information

1
Department of Medicine, University of California, San Diego, California, USA. xiyuan@ucsd.edu

Abstract

Activity of voltage-gated potassium (Kv) channels controls membrane potential, which subsequently regulates cytoplasmic free calcium concentration ([Ca2+]cyt) in pulmonary artery smooth muscle cells (PASMCs). Acute hypoxia inhibits Kv channel function in PASMCs, inducing membrane depolarization and a rise in [Ca2+ ]cyt that triggers vasoconstriction. Prolonged hypoxia inhibits expression of Kv channels and reduces Kv channel currents in PASMCs. The consequent membrane depolarization raises [Ca2+]cyt, thus stimulating PASMC proliferation. The present review discusses recent evidence for the involvement of Kv channels in initiation of hypoxic pulmonary vasoconstriction and in chronic hypoxia-induced pulmonary hypertension.

PMID:
11667964
PMCID:
PMC59541
DOI:
10.1186/rr11
[Indexed for MEDLINE]
Free PMC Article

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