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Respir Res. 2000;1(1):30-5. Epub 2000 Jun 20.

From fruitflies to mammals: mechanisms of signalling via the Sonic hedgehog pathway in lung development.

Author information

1
Lung Biology Research Program, Hospital for Sick Children Research Institute, Toronto, Canada.

Abstract

The hedgehog signalling pathway has been implicated in many different processes in fly and vertebrate development. It is now known that the hedgehog cascade is crucial for the patterning of the early respiratory system. Hedgehog signalling in the lung involves Gli transcription proteins, but their potential downstream target genes have yet to be identified. Bmp4 and Fgf10 have been shown to regulate lung branching morphogenesis but seem not to be targets of hedgehog signalling.

PMID:
11667962
PMCID:
PMC59539
DOI:
10.1186/rr9
[Indexed for MEDLINE]
Free PMC Article

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