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Am J Obstet Gynecol. 2001 Oct;185(4):804-7.

Correlation of quantitative protein measurements in 8-, 12-, and 24-hour urine samples for the diagnosis of preeclampsia.

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Department of Obstetrics and Gynecology, Good Samaritan Hospital, and the E. Kenneth Hatton MD Institute for Research and Education, Cincinnati, OH, USA.



The purpose of this study is to determine if a patient's 8- and/or 12-hour urine total protein values correlate with the 24- hour value to confirm the diagnosis of preeclampsia.


The study population included 65 patients with hypertensive disorders of pregnancy. Patients' urine was collected over 24 hours with the first 8 hours, next 4 hours, and remaining 12 hours collected in separate containers. The urine volume, and total protein and creatinine levels were measured in the 8-, 12-, and 24-hour samples. The 8- and 12-hour results were compared to the 24-hour results by use of simple regression analysis.


Of the 65 patients, 20 had no proteinuria, 37 had mild proteinuria, and 8 had severe proteinuria. The results of the 8- hour sample correlated with those of the 24-hour sample for patients with mild (P <.001) and severe disease (P =.003). The 12-hour sample correlated with the 24-hour sample for patients with no disease (P <.001), mild proteinuria (P <.001), and severe proteinuria (P =.0003).


Total protein values for 8- and 12-hour urine samples correlate positively with values for 24-hour samples for patients with proteinuria. The results for 12- and 24-hour samples correlate for patients without proteinuria.

[Indexed for MEDLINE]

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