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Surg Oncol Clin N Am. 2001 Oct;10(4):821-32, ix.

Isolated limb perfusion: the European experience.

Author information

1
Multidisciplinary Oncology Center, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland. ferdy.lejeune@chuv.hospvd.ch

Abstract

Isolated limb perfusion (ILP) is a method of cancer treatment allowing the administration of high doses of anticancer agents in a limb surgically isolated from systemic circulation. By using continuous leakage monitoring and using the drug melphalan, a high complete remission rate is obtained in patients with melanoma. In patients with sarcomas, ILP with tumor necrosis factor and melphalan represents a neoadjuvant treatment for limb-sparing surgery. This treatment is the first demonstration of an active anti-angiogenic regimen in the clinic.

PMID:
11641093
[Indexed for MEDLINE]

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