Format

Send to

Choose Destination
Oncogene. 2001 Sep 10;20(40):5595-610.

Translocations involving c-myc and c-myc function.

Author information

1
Division of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, California CA 94305, USA.

Abstract

c-MYC is the prototype for oncogene activation by chromosomal translocation. In contrast to the tightly regulated expression of c-myc in normal cells, c-myc is frequently deregulated in human cancers. Herein, aspects of c-myc gene activation and the function of the c-Myc protein are reviewed. The c-myc gene produces an oncogenic transcription factor that affects diverse cellular processes involved in cell growth, cell proliferation, apoptosis and cellular metabolism. Complete removal of c-myc results in slowed cell growth and proliferation, suggesting that while c-myc is not required for cell proliferation, it acts as an integrator and accelerator of cellular metabolism and proliferation.

PMID:
11607812
DOI:
10.1038/sj.onc.1204595
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center