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Neuron. 2001 Oct 11;32(1):1-3.

Plexin signaling via off-track and rho family GTPases.

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1
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Abstract

Two papers in this issue of Neuron examine new aspects of Semaphorin signaling via Plexin receptors. Winberg et al. present evidence that the transmembrane protein Off-track (OTK) interacts biochemically and genetically with Plexin A and is important for Sema 1a repulsive signaling. Hu et al. examine the coupling of Plexin B to Rac and RhoA and propose that Plexin B signaling involves inhibition of Rac function by direct sequestration and simultaneous activation of RhoA.

PMID:
11604131
DOI:
10.1016/s0896-6273(01)00459-7
[Indexed for MEDLINE]
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