Format

Send to

Choose Destination
See comment in PubMed Commons below
J Am Coll Nutr. 2001 Oct;20(5 Suppl):389S-395S; discussion 396S-397S.

Antiinflammatory activities of lactoferrin.

Author information

1
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA. orlac@bcm.tmc.edu

Abstract

Lactoferrin is a non-heme iron binding glycoprotein produced during lactation and by epithelial cells at mucosal surfaces. The protein is a prominent component of the first line of mammalian host defense and its expression is upregulated in response to inflammatory stimuli. In this paper, the antibacterial and immune modulatory properties of lactoferrin that contribute to host defense are reviewed. In addition, the results of recent preclinical and clinical studies demonstrating that lactoferrin acts as an inhibitor of dermal inflammatory cytokine production are summarized. The results indicate that lactoferrin may act as a potent anti-inflammatory protein at local sites of inflammation including the respiratory and gastrointestinal tracts.

PMID:
11603648
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center