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J Clin Endocrinol Metab. 2001 Oct;86(10):4920-5.

Defective mitochondrial ATP synthesis in oxyphilic thyroid tumors.

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1
Inserm EMI-U 00-18, Laboratoire de Biochimie et Biologie Mol├ęculaire, 4rue Larrey, F-49033 Angers cedex 01, France. Frsavagner@chu-angers.fr

Abstract

Oxyphilic tumors (oncocytomas or H├╝rthle cell tumors) form a rare subgroup of thyroid tumors characterized by cells containing abundant mitochondria. The relationship between the mitochondrial proliferation and the pathogenesis of these tumors is unknown. We have assessed the expression of the mitochondrial ND2 and ND5 (subunits of the nicotinamide adenine dinucleotide dehydrogenase complex) genes and the nuclear UCP2 (uncoupling protein 2) gene in 22 oxyphilic thyroid tumors and matched controls. The consumption of oxygen in mitochondria from tumors was determined by polarography. ATP assays were used to explore the mitochondrial respiratory chain activity and the oxidative phosphorylation coupling in seven fresh thyroid tumors and controls. Adenosine triphosphate synthesis was significantly lower in all the tumors, compared with controls, suggesting that a coupling defect in oxidative phosphorylation may be a cause of mitochondrial hyperplasia in oxyphilic thyroid tumors.

PMID:
11600563
DOI:
10.1210/jcem.86.10.7894
[Indexed for MEDLINE]
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