Format

Send to

Choose Destination
EMBO Rep. 2001 Oct;2(10):893-8.

Irresistible IRES. Attracting the translation machinery to internal ribosome entry sites.

Author information

1
INSERM U397, Institut Louis Bugnard, CHU Rangueil, 31403 Toulouse, France.

Abstract

Studies on the control of eukaryotic translation initiation by a cap-independent recruitment of the 40S ribosomal subunit to internal messenger RNA sequences called internal ribosome entry sites (IRESs) have shown that these sequence elements are present in a growing list of viral and cellular RNAs. Here we discuss their prevalence, mechanisms whereby they may function and their uses in regulating gene expression.

PMID:
11600453
PMCID:
PMC1084086
DOI:
10.1093/embo-reports/kve208
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center