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Antimicrob Agents Chemother. 2001 Nov;45(11):3209-12.

In vitro killing of Candida albicans by fatty acids and monoglycerides.

Author information

1
Institute of Biology, University of Iceland, Reykjavik, Iceland. gudmunb@hi.is

Abstract

The susceptibility of Candida albicans to several fatty acids and their 1-monoglycerides was tested with a short inactivation time, and ultrathin sections were studied by transmission electron microscopy (TEM) after treatment with capric acid. The results show that capric acid, a 10-carbon saturated fatty acid, causes the fastest and most effective killing of all three strains of C. albicans tested, leaving the cytoplasm disorganized and shrunken because of a disrupted or disintegrated plasma membrane. Lauric acid, a 12-carbon saturated fatty acid, was the most active at lower concentrations and after a longer incubation time.

PMID:
11600381
PMCID:
PMC90807
DOI:
10.1128/AAC.45.11.3209-3212.2001
[Indexed for MEDLINE]
Free PMC Article
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