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Cancer. 2001 Sep 15;92(6 Suppl):1678-83.

The biologic basis of fatigue.

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Division of Anesthesiology, Critical and Palliative Care, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030-4095, USA.


In spite of many remarkable advances in our understanding of the mechanisms of cancer biology, very little attention has been directed toward mechanisms underlying cancer-induced symptoms. Although fatigue is a widely prevalent complication of cancer, there is a paucity of both basic and clinical research in this area. This article details our current knowledge of mechanisms causing cancer-related fatigue and briefly discusses currently available therapeutic options. A framework for addressing gaps in our knowledge and recommendations for future research directions are proposed.

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