Format

Send to

Choose Destination
Trends Microbiol. 2001 Oct;9(10):494-500.

The Sec protein-translocation pathway.

Author information

1
Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan.

Abstract

The Sec machinery (or translocase) provides a major pathway of protein translocation from the cytosol across the cytoplasmic membrane in bacteria. The SecA ATPase interacts dynamically with the SecYEG integral membrane components to drive the transmembrane movement of newly synthesized preproteins. This pathway is also used for integration of some membrane proteins and the Sec translocase interacts with other cellular components to achieve its cellular roles. The detailed protein interactions involved in these processes are being actively studied and a structural understanding of the protein-conducting channel has started to emerge.

PMID:
11597451
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center