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Bioorg Med Chem Lett. 2001 Nov 5;11(21):2871-4.

2-(Anilinomethyl)imidazolines as alpha(1)-adrenoceptor agonists: the identification of alpha(1A) subtype selective 2'-carboxylic acid esters and amides.

Author information

1
GlaxoSmithKline, 5Moore Drive, Research Triangle Park, NC 27709, USA. mjb45288@glaxowellcome.com

Abstract

2-(Anilinomethyl)imidazolines with 2'-esters or 2'-amides are potent agonists of the cloned human alpha(1)-adrenoceptors in vitro. The size and shape of the ortho substituent can have significant effects on the potency, efficacy, and subtype selectivity of these 2-(anilinomethyl)imidazolines. alpha(1A)-subtype selective agonists have been identified.

PMID:
11597419
DOI:
10.1016/s0960-894x(01)00569-8
[Indexed for MEDLINE]

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