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Bioorg Med Chem Lett. 2001 Nov 5;11(21):2821-5.

A designed antagonist of the thyroid hormone receptor.

Author information

1
Department of Pharmaceutical Chemistry, University of California, San Francisco, 94143-0446, USA.

Abstract

We synthesized an analogue of the thyromimetic GC-1 bearing the same hydrophobic appendage as the estrogen receptor antagonist ICI-164,384. While having reduced affinity for the thyroid hormone receptors compared to GC-1, it behaves in a manner consistent with a competitive antagonist in a transactivation assay.

PMID:
11597408
DOI:
10.1016/s0960-894x(01)00521-2
[Indexed for MEDLINE]

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