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J Med Virol. 2001 Nov;65(3):576-83.

Human herpesvirus 6 downregulates major histocompatibility complex class I in dendritic cells.

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Department of Microbiology, Osaka University Medical School, Yamada-oka, Suita, Osaka 565-0871, Japan.


The expression of major histocompatibility complex (MHC) class I, class II, CD1a, and CD 83 in dendritic cells (DCs) after infection with human herpesvirus 6 (HHV-6) was examined. Whereas there was no significant change in the expression of CD1a, CD83, and MHC class II in infected DCs, MHC class I expression was downregulated after infection with HHV-6 variant A but not HHV-6B. The expression of HHV-6 immediate-early or early genes was required for the downregulation of MHC class I. The de novo synthesis of MHC class I was greatly suppressed by infection with HHV-6A in DCs, while its rate of degradation was only slightly elevated. These results suggest that HHV-6A may escape from the host immune system in DCs by causing the downregulation of MHC class I synthesis.

[Indexed for MEDLINE]

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