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Toxicon. 2001 Nov;39(11):1793-803.

Understanding the mode of action of diphtheria toxin: a perspective on progress during the 20th century.

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Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.


Diphtheria toxin is one of the most extensively studied and well understood bacterial toxins. Ever since its discovery in the late 1800's this toxin has occupied a central focus in the field of toxinology. In this review, I present a chronology of major discoveries that led to our current understanding of the structure and activity of diphtheria toxin.

[Indexed for MEDLINE]

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