Format

Send to

Choose Destination
See comment in PubMed Commons below
Arch Dermatol. 2001 Oct;137(10):1309-13.

Identification of clonal T cells in the blood of patients with systemic sclerosis: positive correlation with response to photopheresis.

Author information

1
Department of Dermatology, Geneva University Hospital, 24, rue Micheli-du-Crest, CH-1211 Genève 14 Switzerland. french@cmu.unige.ch

Abstract

OBJECTIVES:

To search for circulating clonal T-cell populations in patients with systemic sclerosis (SSc), and to determine whether T-cell clonality in the blood predicts therapeutic response to photopheresis.

DESIGN:

Analysis of clonal T-cell receptor gamma gene rearrangements before photopheresis treatment and blinded clinical evaluation of cutaneous response to photopheresis in a case series.

SETTING:

University hospital setting.

PATIENTS:

Thirteen consecutive patients with SSc.

INTERVENTIONS:

Photopheresis in 11 patients.

MAIN OUTCOME MEASURES:

Clonality of T cells in the blood before photopheresis and clinical response to photopheresis.

RESULTS:

Screening of blood samples from 13 SSc patients for clonal T-cell receptor gamma gene rearrangements revealed a monoclonal T cell population in 6 (46%) of 13 SSc patients. Clinical response to photopheresis in 11 patients was evaluated in a blinded manner using skin severity scores. Clonality of T cells appeared to be associated with a higher chance of response to photopheresis therapy, as 4 (67%) of 6 patients in the clone-positive group vs 1 (20%) of 5 in the clone-negative group experienced a clinically significant response to treatment.

CONCLUSIONS:

A high proportion of patients with SSc have detectable expanded clonal T-cell populations in the peripheral blood, and such patients appear more likely to respond to photopheresis.

PMID:
11594854
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems
    Loading ...
    Support Center