Format

Send to

Choose Destination
See comment in PubMed Commons below
Psychopharmacology (Berl). 2001 Sep;157(2):163-7.

Effects of short-term citicoline treatment on acute cocaine intoxication and cardiovascular effects.

Author information

1
Behavioral Psychopharmacology Research Laboratory, McLean Hospital/Havard Medical School, Belmont, MA 02478, USA. lukas@mclean.org

Abstract

RATIONALE:

The majority of pharmacotherapies proposed for cocaine dependence have been marginally effective and frequently have undesirable side effects. We recently demonstrated that short-term treatment with citicoline decreased self-reported desire to use cocaine in crack cocaine users.

OBJECTIVE:

The present study was conducted to assess the safety of citicoline in combination with cocaine by investigating whether cocaine-induced cardiovascular and behavioral effects and cocaine plasma levels are altered by citicoline pretreatment.

METHODS:

Eight healthy male and female volunteers who used cocaine on an occasional basis participated in this randomized, placebo-controlled, three-visit study. During all three visits, subjects received an acute intranasal dose of cocaine (0.9 mg/kg) and were continuously monitored for the ensuing 3.5 h. The first visit involved no pretreatment, and visits 2 and 3 were preceded by a 4-day pretreatment period of either citicoline (1 g/day) or placebo.

RESULTS:

Citicoline pretreatment did not alter the cardiovascular, physiologic, or subjective effects of acute cocaine.

CONCLUSIONS:

Although citicoline did not block the acute subjective effects of cocaine in a laboratory environment, the combined use of citicoline and a moderate dose of intranasal cocaine presented no added risk of cardiovascular effects. Further study is necessary to determine whether this medication (which is currently used to treat strokes) will be a useful adjunct to treat cocaine dependence.

PMID:
11594440
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Loading ...
    Support Center