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Arq Neuropsiquiatr. 2001 Sep;59(3-B):806-8.

Orbital apex syndrome due to aspergillosis: case report.

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Disciplina de Neurocirurgia, Departamento Neurologia, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, SP, Brasil.


We report the case of a 73-year-old female who presented facial numbness and pain in the first division of the trigeminal nerve, ptosis, diplopia and visual loss on the right side for the previous four months. The neurological, radiological and histological examination demonstrated a rare case of invasive fungal aspergillosis of the central nervous system, causing orbital apex syndrome, later transformed in temporal brain abscess. She died ten months later due to respiratory and renal failure in spite of specific antimycotic therapy.

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