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Bioorg Med Chem Lett. 2001 Oct 22;11(20):2763-7.

Simplified catechin-gallate inhibitors of HIV-1 reverse transcriptase.

Author information

1
Department of Medicinal and Biological Chemistry, College of Pharmacy, University of Toledo, Toledo, OH 43606, USA.

Abstract

Systematic simplification of the molecular structures of epicatechin gallate and epigallocatechin gallate to determine the minimum structural characteristics necessary for HIV-1 reverse transcriptase inhibition in vitro resulted in several compounds that strongly inhibited the native as well as the A17 double mutant (K103N Y181C) enzyme, which is normally insensitive to most known nonnucleoside inhibitors.

PMID:
11591519
DOI:
10.1016/s0960-894x(01)00577-7
[Indexed for MEDLINE]

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