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Bioorg Med Chem Lett. 2001 Oct 22;11(20):2759-62.

Potent second generation vinyl sulfonamide inhibitors of the trypanosomal cysteine protease cruzain.

Author information

1
Department of Chemistry, University of Michigan, Ann Arbor, 48109, USA. roush@umich.edu

Abstract

A new family of potent N-alkoxyvinylsulfonamide inhibitors of cruzain have been developed. Inhibitor 13 has a second order inactivation rate constant of 6,480,000s(-1)M(-1) versus cruzain, and is also highly effective against Trypanosoma cruzi trypomastigotes in a tissue culture assay.

PMID:
11591518
[Indexed for MEDLINE]

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