Format

Send to

Choose Destination
Bioorg Med Chem Lett. 2001 Oct 22;11(20):2715-7.

Synthesis of N-propargylphenelzine and analogues as neuroprotective agents.

Author information

1
CV Technologies Inc., Edmonton Research Park, 9411-20 Ave., Edmonton, T6N 1E5, Alberta, Canada. linglei@cvtechnologies.com

Abstract

A series of N(1)- and N(2)-propargylphenelzine derivatives and analogues (1-7) was synthesized. In addition to their activity as monoamine oxidase inhibitors, two of the compounds, N(1)- and N(2)-propargylphenelzines (3 and 6), were found to be potent at preventing DSP-4-induced noradrenaline (NA) depletion in mouse hippocampus, suggesting that they have neuroprotective properties.

PMID:
11591508
DOI:
10.1016/s0960-894x(01)00549-2
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center