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Hong Kong Med J. 2001 Sep;7(3):299-302.

Triiodothyronine augmentation for the treatment of depression in substance misusers unresponsive to tricyclic antidepressants.

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Department of Psychiatry, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong.


We report on two substance misusers with depression resistant to tricyclic antidepressant treatment who responded to triiodothyronine augmentation. The management of resistant depression, augmentation strategies with particular reference to triiodothyronine, and the possible mechanism of action of triiodothyronine are discussed.

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