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Lancet. 2001 Sep 29;358(9287):1066-7.

Plasmodium falciparum cross-resistance between trimethoprim and pyrimethamine.

Abstract

Trimethoprim-sulfamethoxazole has been recommended as part of the standard package of care for people with HIV and AIDS in Africa. A similar antifolate combination, sulfadoxine-pyrimethamine, is now the first-line antimalarial drug in several of the African countries with the highest rates of HIV infection. We present evidence of Plasmodium falciparum cross-resistance between trimethoprim and pyrimethamine at the molecular level. The impact of trimethoprim-sulfamethoxazole on the efficacy of sulfadoxine-pyrimethamine needs to be assessed urgently, and alternative antimalarial treatment should be considered for people on trimethoprim-sulfamethoxazole prophylaxis.

PMID:
11589941
DOI:
10.1016/S0140-6736(01)06201-8
[PubMed - indexed for MEDLINE]
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