Format

Send to

Choose Destination
J Am Acad Child Adolesc Psychiatry. 2001 Oct;40(10):1215-21.

Adolescent anorexia nervosa: the catch-up effect in bone mineral density after recovery.

Author information

1
Section of Child and Adolescent Psychiatry, Institute of Psychiatry and Psychology, Hospital Clinic Universitari, Barcelona, Spain. 16812jcf@comb.es

Abstract

OBJECTIVE:

To determine whether bone mineral density (BMD) loss can be reversed in adolescent anorexic patients.

METHOD:

A prospective study with 108 anorexia nervosa patients (DSM-IV) from 12 to 17 years of age at the Eating Disorders Unit in the Hospital Clinic of Barcelona (Spain). They were first evaluated by dual-energy x-ray absorptiometry in lumbar spine and femoral neck consecutively from 1997 until 1999 and reexamined after 6 to 30 months. Results were compared with normative values of bone mass.

RESULTS:

Patients with poor outcome (n = 44) had a bone mass loss. Patients with good short-term outcome were divided in two groups. The group with normal BMD at first evaluation (n = 41) had a bone mass gain per year of 3.0% at lumbar spine and 0.5% at femoral neck. The group with low BMD at first evaluation (n = 23) had an increase per year of 9.1% at lumbar spine and 4.5% at femoral neck. In a multiple linear regression analysis with the variables body mass index, age, months with menstruation, and BMD zscore at first evaluation, the only predictor of BMD increase was the first z score both at the lumbar spine (coefficient R = 0.64; p < .001) and at the femoral neck (coefficient R = 0.5; p < .001).

CONCLUSIONS:

There is a catch-up effect in adolescent patients with low BMD but good short-term outcome.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center