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Vet Immunol Immunopathol. 2001 Oct;82(3-4):203-14.

Cannabinoids inhibit nitric oxide production in bone marrow derived feline macrophages.

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Department of Animal Pathology, Hygiene and Veterinary Public Health, Microbiology and Immunology Unit, via Celoria 10, 20133 Milano, Italy.


Feline immunodeficiency virus (FIV) infection causes a widespread natural immunodeficiency syndrome in cats that is considered a suitable animal model for studying human immunodeficiency virus (HIV) infection and pathogenesis. Short term cultures of bone marrow derived feline macrophages stimulated with recombinant feline interferon-gamma (r-IFN-gamma) and lipopolysaccharide (LPS) were shown to produce nitric oxide. Feline macrophages were shown to express cannabinoid receptors, and nitric oxide production decreased after in vitro exposure to synthetic cannabinoid CP-55940. Both cannabinoid receptors, CB1 and CB2, were involved in this process, since the inhibition was reversed by selective cannabinoid antagonists for both of these receptors.

[Indexed for MEDLINE]

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