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Med J Aust. 2001 Sep 3;175(5):264-7.

Risk of death from methicillin-resistant Staphylococcus aureus bacteraemia: a meta-analysis.

Author information

1
Infection Management Services, Princess Alexandra Hospital, Brisbane, QLD. whitbym@health.qld.gov.au

Abstract

OBJECTIVE:

To estimate the risk of death from healthcare-associated (nosocomial) bacteraemia caused by methicillin-resistant Staphylococcus aureus (MRSA), and compare it with that of nosocomial bacteraemia caused by methicillin-sensitive S. aureus (MSSA), by meta-analysis of selected studies.

DATA SOURCES:

Medline, EMBASE, Current Contents and Cochrane Library were searched for the period January 1978 (or earliest date of the database, if later than 1978) to December 2000.

STUDY SELECTION:

Studies which compared mortality of nosocomial MRSA and MSSA bacteraemia.

DATA SYNTHESIS:

Nine studies were analysed. All but one found an increased relative risk (RR) of death from MRSA bacteraemia, with RR ranging from 0.89 to 4.94. Meta-analysis showed that patients with MRSA bacteraemia have an RR of death, compared with patients with MSSA bacteraemia, of 2.12 (95% CI, 1.76-2.57) using the fixed-effect method, and 2.03 (95% CI, 1.55-2.65) using the random-effect method.

CONCLUSION:

MRSA bacteraemia is associated with a real increase in risk of death, further justifying ongoing MRSA surveillance and control in healthcare facilities.

PMID:
11587259
[Indexed for MEDLINE]

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