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Ann Clin Biochem. 2001 Sep;38(Pt 5):459-70.

Diagnosis and clinical biochemistry of inherited tubulopathies.

Author information

1
Department of Physiological Sciencesy, University of Newcastle upon Tyne, UK. j.a.sayer@ncl.ac.uk

Abstract

Epithelial ion channels and transporter proteins have physiologically important roles throughout the length of the nephron. Discovering the molecular identities of tubular epithelial cell proteins and their functional roles has increased understanding of both renal physiology and tubular diseases. Defects in tubular handling of solutes may present with nephrocalcinosis or nephrolithiasis, rickets, acid base, electrolyte or blood pressure disturbances. Biochemical analysis of both serum and urine, together with clinical history and examination, remain fundamental for their diagnosis, whilst understanding of underlying molecular mechanisms allows appropriate management.

PMID:
11587124
DOI:
10.1177/000456320103800503
[Indexed for MEDLINE]

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