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Ophthalmic Res. 2001 Sep-Oct;33(5):251-5.

Aqueous humor and serum tumor necrosis factor-alpha in clinical uveitis.

Author information

  • 1Department of Ophthalmology, Reina Sofia University Clinic, Cordoba, Spain. med000346@nacom.es

Abstract

OBJECTIVE:

To study the local and systemic behavior of the tumor necrosis factor-alpha (TNF-alpha) in patients with active uveitis.

METHODS:

TNF-alpha levels were measured in aqueous humor and peripheral blood samples using an enzyme-linked immunosorbent assay from 23 patients with uveitis and 16 control patients who had been operated on for uncomplicated cataracts.

RESULTS:

Aqueous humor and sera of patients with uveitis showed higher levels of TNF-alpha than those of controls (p < 0.001). A comparison of cytokine levels between aqueous humor and sera showed significantly higher levels of TNF-alpha in serum than aqueous humor (p < 0.001). Correlation studies using the regression test for successive steps showed that serum TNF-alpha levels correlated with recurrent uveitis (r = 0.4150; p = 0.0489).

CONCLUSIONS:

TNF-alpha is a cytokine that participates actively in the pathogenesis of clinical uveitis. Our data emphasize the greater systemic than local participation of TNF-alpha. Finally, an elevated serum TNF-alpha seems to be associated with a recurrent pattern of uveitis.

PMID:
11586057
DOI:
55677
[PubMed - indexed for MEDLINE]
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