Heavy metal pollutants generated by mining activities in the Jordanian desert c. 2000 years ago will have had detrimental effects on the health of slaves, guards and expert overseers. The pollutants continue to persist and cycle in the modern environment and affect plants, animals and inevitably the humans who are dependent on both. These findings have implications in terms of the public health of human populations living on or in the vicinity of ancient industrial sites around the Mediterranean and in the Middle East. Some effects of heavy metals on human health are examined; issues of bioaccumulation and partitioning are addressed.