Format

Send to

Choose Destination
Mol Cell. 2001 Sep;8(3):683-91.

Specificity of MAP kinase signaling in yeast differentiation involves transient versus sustained MAPK activation.

Author information

1
Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697, USA.

Abstract

Signals transmitted by common components often elicit distinct (yet appropriate) outcomes. In yeast, two developmental options-mating and invasive growth-are both regulated by the same MAP kinase cascade. Specificity has been thought to result from specialized roles for the two MAP kinases, Kss1 and Fus3, and because Fus3 prevents Kss1 from gaining access to the mating pathway. Kss1 has been thought to participate in mating only when Fus3 is absent. Instead, we show that Kss1 is rapidly phosphorylated and potently activated by mating pheromone in wild-type cells, and that this is required for normal pheromone-induced gene expression. Signal identity is apparently maintained because active Fus3 limits the extent of Kss1 activation, thereby preventing inappropriate signal crossover.

PMID:
11583629
PMCID:
PMC3017497
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center