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J Antimicrob Chemother. 2001 Oct;48(4):549-52.

Fluoroquinolone susceptibilities of efflux-mediated multidrug-resistant Pseudomonas aeruginosa, Stenotrophomonas maltophilia and Burkholderia cepacia.

Author information

1
Department of Microbiology and Immunology, Queen's University, Kingston, Ontario, Canada K7L 3N6.

Abstract

The antibacterial activities of seven fluoroquinolones (ciprofloxacin, BAYy3118, clinafloxacin, gemifloxacin, moxifloxacin, sparfloxacin and trovafloxacin) against isogenic efflux-mediated multidrug-resistant strains of Pseudomonas aeruginosa, Stenotrophomonas maltophilia and Burkholderia cepacia, were compared. The results indicate that these fluoroquinolones are all substrates for the multidrug efflux systems of these organisms. Clinafloxacin was found generally to be the most active agent against multidrug-resistant strains.

PMID:
11581236
DOI:
10.1093/jac/48.4.549
[Indexed for MEDLINE]

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