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AIDS. 2001 Sep 28;15(14):1887-90.

Highly active antiretroviral therapy induces specific changes in effector and central memory T cell sub-populations.

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Service of Clinical Immunology, Department of Internal Medicine, Ancona University Medical School, Italy.


Highly active antiretroviral therapy (HAART) improves the immunodeficiency of HIV-infected individuals. In this report we show that HAART increases both naive (CD45RA+CD62L+) and central memory (CD45RO+CD62L+) CD4 lymphocytes. On CD8 lymphocytes, HAART induces an increase of naive cells associated with a consistent decrease of effector cells (CD45 RO+CD62L-). No specific differences in phenotypic changes were observed with different HAART regimens, suggesting that, once viral suppression is achieved, the pharmacological class of antiretroviral drugs does not affect immune reconstitution.

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