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Postgrad Med. 2001 Sep;110(3):87-8, 91-4.

NSAID-related gastrointestinal injury. Evidence-based approach to a preventable complication.

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1
Division of Gastroenterology, Mail Code PV-310, Oregon Health and Science University School of Medicine, 3181 SW Sam Jackson Park Rd, Portland, OR 97201-3098, USA. fennerty@ohsu.edu

Abstract

NSAID-induced gastrointestinal mucosal injury and its subsequent complications are a tremendously important clinical problem. Effective prophylactic and treatment strategies involve proton pump inhibitors, misoprostol, or selective COX-2 inhibitors. These agents are capable of dramatically decreasing or eliminating the risk of mucosal injury as well as the morbidity and mortality for this disorder. Identification of the at-risk patient and initiation of appropriate preventive therapy are the keys to minimizing the societal burden of this disease process.

PMID:
11570208
DOI:
10.3810/pgm.2001.09.1020
[Indexed for MEDLINE]
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