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Neuroreport. 2001 Oct 8;12(14):3019-22.

Neonatal novelty exposure modulates hippocampal volumetric asymmetry in the rat.

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  • 1Departments of Psychology, University of New Mexico, Albuquerque, NM 87131, USA.


Early life environmental manipulations have been shown to affect hippocampal-dependent learning, hippocampal volume and cerebral lateralization. In this study, we investigated the effects of neonatal stimulation on hippocampal volumetric asymmetry. Long-Evans hooded rats were exposed to a novel non-home environment 3 min daily for the first 3 weeks of life. Histological measures of the left and right hippocampus were made at 8 months of age. We found that neonatal novelty exposure resulted in a long-lasting change in hippocampal volumetric asymmetry. Specifically, this brief and transient early life stimulation increased the right hippocampal volumetric dominance at mid-adulthood.

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