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Br J Ophthalmol. 2001 Oct;85(10):1171-3.

Retinopathy in chronic hepatitis C patients during interferon treatment with ribavirin.

Author information

1
Department of Ophthalmology, University Health Network, Toronto Western Hospital, University of Toronto, Ontario, Canada.

Abstract

AIM:

To assess the ocular effect of interferon alfa 2b prescribed with ribavirin in patients undergoing therapy for chronic hepatitis C.

METHODS:

19 patients with chronic hepatitis C who satisfied the follow up criteria were assessed for ocular complications using slit lamp biomicroscopy and indirect ophthalmoscopy before, during, and after the treatment at regular intervals.

RESULTS:

8/19 patients, while on treatment, developed an asymptomatic retinopathy. Among these 3/8 were relapsers and 5/9 were non-responders to interferon monotherapy. All retinal changes faded, often while the patients continued the therapy. There was no significant association in occurrence of retinopathy with haematological and/or biochemical changes.

CONCLUSION:

Retinopathy was more common in interferon monotherapy non-responders than relapsers when treated with interferon alfa 2b with the addition of ribavirin. The changes were transient, disappearing while the patients were still being treated.

PMID:
11567959
PMCID:
PMC1723748
[Indexed for MEDLINE]
Free PMC Article

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