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Trends Cell Biol. 2001 Oct;11(10):426-33.

Integrating stress-response and cell-cycle checkpoint pathways.

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Cell Cycle Laboratory, MRC Radiation and Genome Stability Unit, Harwell, OX11 0RD, Didcot, UK.


The DNA integrity checkpoint and stress kinase (SAPK/JNK and p38) pathways function to modulate cell-cycle, apoptotic and transcriptional responses to stress. Although initially considered to function independently, recent advances indicate a number of links between the stress-response and checkpoint pathways. Here, we consider the relationship between the stress-response and checkpoint pathways and how they interact to modulate cell-cycle control.

[Indexed for MEDLINE]

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