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Cancer Lett. 2001 Oct 30;172(2):193-8.

Effects of maitake (Grifola frondosa) D-Fraction on the carcinoma angiogenesis.

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Department of Microbial chemistry, Kobe Pharmaceutical University, 19-1, Motoyama-kitamachi 4-chome, Higashinada-ku, 658-8558, Kobe, Japan.


We have reported that D-Fraction extracted from maitake (Grifola frondosa), activates immune competent cells, and indicates anti-tumor activities. The D-Fraction was observed to induce angiogenesis in vivo and to enhance the proliferation capability and migration capability of human vascular endothelial cell in vitro. The D-Fraction also increased plasma vascular endothelial growth factor (VEGF) concentration significantly. Also VEGF and TNF-alpha production by the activated peritoneal macrophages were enhanced. These results suggest that the anti-tumor activity of the D-Fraction is not only associated with the activation of the immuno-competent cells but also possibly related to the carcinoma angiogenesis induction.

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