Format

Send to

Choose Destination
Cancer Lett. 2001 Oct 30;172(2):193-8.

Effects of maitake (Grifola frondosa) D-Fraction on the carcinoma angiogenesis.

Author information

1
Department of Microbial chemistry, Kobe Pharmaceutical University, 19-1, Motoyama-kitamachi 4-chome, Higashinada-ku, 658-8558, Kobe, Japan.

Abstract

We have reported that D-Fraction extracted from maitake (Grifola frondosa), activates immune competent cells, and indicates anti-tumor activities. The D-Fraction was observed to induce angiogenesis in vivo and to enhance the proliferation capability and migration capability of human vascular endothelial cell in vitro. The D-Fraction also increased plasma vascular endothelial growth factor (VEGF) concentration significantly. Also VEGF and TNF-alpha production by the activated peritoneal macrophages were enhanced. These results suggest that the anti-tumor activity of the D-Fraction is not only associated with the activation of the immuno-competent cells but also possibly related to the carcinoma angiogenesis induction.

PMID:
11566496
DOI:
10.1016/s0304-3835(01)00652-8
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center